Every ingredient. Explained.

An adaptogenic herb used for centuries in Ayurvedic medicine. KSM-66® is the world's most studied ashwagandha extract, standardized to a minimum 5% withanolides. In dogs, it supports the hypothalamic-pituitary-adrenal (HPA) axis, helping regulate the stress response and reduce cortisol levels. Particularly effective for situational anxiety — vet visits, travel, environmental changes.

Beta-glucans are natural polysaccharides derived from yeast cell walls. Wellmune® is the most clinically studied beta-glucan, shown to prime the immune system's innate defense mechanisms. In dogs, regular supplementation supports immune surveillance and is particularly valuable during periods of stress (which significantly suppresses immune function).

Biotin is a water-soluble B vitamin essential for keratin production — the structural protein that forms the basis of hair, nails, and skin. In dogs, biotin deficiency presents as dull coat, hair loss, scaly skin, and brittle nails. Supplementation at therapeutic doses supports coat shine and skin barrier integrity. Our formulas use D-Biotin, the naturally occurring, most bioavailable form.

Chamomile's active compound, apigenin, binds to GABA receptors in the brain — the same mechanism as many anti-anxiety medications, but without the sedation. Our extract is standardized to ensure consistent apigenin content in every batch. Shown to reduce acute anxiety symptoms and support restful sleep patterns in companion animals.

Boswellia works through a distinct mechanism from most anti-inflammatory agents — it specifically inhibits 5-LOX, an enzyme that drives leukotriene synthesis (a key inflammatory pathway in joint tissue). Several randomized controlled trials in dogs have shown significant improvement in mobility, lameness scores, and pain assessment when compared to placebo. One of the few herbal ingredients with robust canine-specific evidence.

Chondroitin is a structural component of cartilage, providing resistance to compression and retaining water within the joint matrix. When used alongside glucosamine, it inhibits enzymes that degrade cartilage and reduces inflammatory cytokine activity in synovial tissue. We use CS-Bioactive®, the only chondroitin compound tested for efficacy specifically in dogs and other companion animals.

Hydrolyzed collagen peptides are broken down into small molecular weight fragments that can be directly absorbed through the gut wall. Once absorbed, they act as signaling molecules that stimulate fibroblasts to produce new collagen — essentially telling the body to rebuild its own structural proteins. Marine-sourced Type I collagen has been shown to improve skin elasticity, hydration, and barrier function.

CoQ10 is a fat-soluble antioxidant present in virtually every cell, with the highest concentrations in energy-demanding tissues: heart, skeletal muscle, and kidney. It serves as an essential electron carrier in the mitochondrial electron transport chain. Natural CoQ10 production declines significantly with age. We use Ubiquinol (the reduced, active form), which has 2-3x higher bioavailability than conventional ubiquinone.

DHA is the predominant structural fatty acid in brain gray matter, comprising up to 40% of total polyunsaturated fatty acids in the brain. It is essential for synaptic membrane fluidity, neurotransmitter signaling, and neuroinflammation regulation. In puppies, DHA is critical for cognitive development. In adult and senior dogs, supplementation supports memory retention and reduces cognitive decline. Also plays a key role in maintaining the skin lipid barrier.

Ginger's bioactive compounds — gingerols and shogaols — accelerate gastric motility (the speed at which food moves through the stomach), reducing nausea, bloating, and gas. It also has mild anti-inflammatory effects on the gut lining. Particularly beneficial for dogs prone to motion sickness or sensitive-stomach issues. Safe and well-tolerated at supplemental doses.

Glucosamine is a natural precursor to glycosaminoglycans — the structural molecules that make up cartilage. As dogs age, glucosamine synthesis declines and cartilage begins to break down faster than it's replaced. Supplementation provides the raw materials for cartilage repair and has been shown to reduce pain scores and improve mobility in dogs with osteoarthritis. We use GreenGrown®, a plant-based, non-shellfish source suitable for dogs with seafood sensitivities.

Inulin is a soluble prebiotic fiber that selectively feeds beneficial gut bacteria — primarily Bifidobacterium and Lactobacillus species. Unlike probiotics (which add new bacteria), prebiotics feed the bacteria already present. The two work synergistically: our probiotic formula pairs Bacillus coagulans with inulin to support both bacterial survival and proliferation throughout the gut.

L-Carnitine is a conditionally essential nutrient that transports long-chain fatty acids into the mitochondria for energy production. Without adequate carnitine, fat cannot be efficiently converted to fuel — particularly in cardiac and skeletal muscle. In dogs, supplementation has been shown to support lean body mass, reduce fat accumulation, and improve exercise tolerance. Also plays a documented role in canine dilated cardiomyopathy (DCM) management.

L-Theanine is an amino acid found naturally in green tea. It promotes alpha brain wave activity — associated with a relaxed, alert state — without causing sedation. It works by modulating glutamate receptors and increasing GABA, serotonin, and dopamine levels. We use Suntheanine®, produced through an enzymatic fermentation process that yields 100% pure L-theanine (the only isomer with demonstrated calming activity). Particularly well-studied for noise aversion and situational anxiety in dogs.

MSM is a naturally occurring organosulfur compound that provides the sulfur required for the synthesis of collagen, glucosamine, and chondroitin — all critical components of cartilage and connective tissue. It also has direct anti-inflammatory effects through NF-κB pathway inhibition. OptiMSM® uses a proprietary distillation process (rather than crystallization) that yields exceptional purity and removes contaminants and heavy metals.

NMN is a direct precursor to NAD+ (Nicotinamide Adenine Dinucleotide) — the molecule that powers virtually every energy-producing reaction in the cell. NAD+ levels decline by approximately 50% between young adulthood and middle age in mammals, correlating closely with fatigue, reduced recovery, and the onset of age-related decline. NMN bypasses rate-limiting steps in NAD+ synthesis, making it the most direct and efficient way to restore cellular NAD+ levels.

EPA and DHA are long-chain omega-3 fatty acids with extensive evidence across joint health, skin barrier function, cardiac health, cognitive function, and inflammatory regulation. Triglyceride-form omega-3 (as used in EPAX®) absorbs 70% more efficiently than ethyl ester forms. In dogs, EPA is particularly potent for reducing systemic inflammation, while DHA supports brain and retinal health. Among the most evidence-backed supplements for companion animals.

Phosphatidylserine is a phospholipid that makes up a critical component of neuronal cell membranes. It supports neurotransmitter release, glucose metabolism in the brain, and the survival of neurons under oxidative stress. In aging dogs, declining PS levels are associated with cognitive dysfunction syndrome (CDS). Supplementation has been shown to support learning, memory, and orientation in senior dogs. Our sunflower-derived PS avoids soy allergens.

Unlike fragile probiotic strains that die in stomach acid, Bacillus coagulans forms protective spores that survive the journey to the lower GI tract — where they're needed. GanedenBC30® is the most studied spore-forming probiotic, with demonstrated benefits for stool quality, bowel regularity, and immune modulation in dogs. Heat-stable to 160°F, making it compatible with manufacturing processes that kill most conventional probiotics.

Dogs synthesize their own vitamin C in the liver, but this production decreases under stress, illness, and aging — creating a meaningful supplemental need. Vitamin C is essential for collagen synthesis, immune cell function, and neutralizing free radicals. We use Ester-C®, a buffered calcium ascorbate that is gentler on the digestive tract than ascorbic acid and has been shown to remain in white blood cells longer than standard forms.

Zinc is involved in over 300 enzymatic reactions and is essential for immune cell development, wound healing, protein synthesis, and skin barrier integrity. Zinc deficiency is common in dogs and presents as dry, flaky skin, hair loss, and impaired wound healing. We use Albion® chelated zinc bisglycinate, which absorbs 2-3x more efficiently than zinc oxide and has significantly lower gastrointestinal irritation.